There are four main ED medications: sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra). These medicines enhance the effects of nitric oxide, a chemical produced by your body in response to sexual stimulation.

Taking medication alone can help, but a doctor should also check you for any health conditions that might contribute to your ED.

Sildenafil

Sildenafil, which is sold under the brand name Viagra, is an oral medication that improves blood flow to help men with erectile dysfunction get and keep an erection. It's a cure, but it can help.

Kamagra Oral Jelly Australia works by blocking a substance called phosphodiesterase type 5, which breaks down cGMP in the corpus cavernosum. When cGMP levels are higher, an erection can occur in response to sexual stimulation. It's important to take the medicine on an empty stomach, and it shouldn't be combined with fatty foods or alcohol because it can slow the effects.

It's also used to treat pulmonary arterial hypertension (PAH). Clinical trials in children with PAH related to sickle cell disease have been small, but sildenafil seems safe and effective. Mild liver disease doesn't appear to require a dose adjustment, and mild to moderate kidney disease hasn't been reported as a problem. However, it's not recommended for use in patients with severe liver or kidney problems.

Tadalafil

Tadalafil, the non-branded version of Cialis, is an oral treatment for erectile dysfunction that improves blood flow to the penis to produce a stronger and longer-lasting erection. Vidalista 40mg medicine works by blocking PDE5, a chemical that breaks down cGMP in the body, and can last up to 36 hours after taking it.

It can also treat the signs and symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate), including difficulty urinating, painful urination, and a frequent or urgent need to urinate. It is also used to improve exercise capacity in people with pulmonary arterial hypertension (PAH; high pressure in the vessels carrying blood to the lungs).

This medication can interact with certain medicines, including those that treat heart conditions such as nitrates and alpha-blockers. You should tell your doctor about any medications you are taking before starting tadalafil. You should also avoid consuming alcohol while taking this medicine.

Vardenafil

The medication vardenafil (Levitra) works by helping the blood vessels that carry blood to the penis become more relaxed, allowing the penis to engorge and get an erection. It also helps the penis stay inflated longer during sexual activity.

The medicine works by inhibiting an enzyme called phosphodiesterase-5 (PDE5). This prevents the degradation of cyclic guanosine monophosphate (cGMP) and allows cGMP to remain longer in the bloodstream.

In flexible-dose clinical trials, vardenafil improved the IIEF domain score and ability to have an erection long enough for intercourse in patients with spinal cord injury over a three-month treatment period.

Some people who take vardenafil may experience nausea, which is generally mild and short-lived. People with certain heart conditions should discuss this medication with a doctor, as it can cause changes to the QT interval in some people.

Avanafil

Stendra (avanafil) is a PDE5 inhibitor that works to treat erectile dysfunction in men. Like Viagra, it increases blood flow to the penis in conjunction with sexual stimulation so that you can achieve and maintain an erection. Stendra is only available by prescription and should be taken as a 100 mg or 200 mg dose approximately 15 minutes before sexual activity.

Avanafil works by preventing the action of an enzyme called phosphodiesterase type 5 that normally breaks down cyclic guanosine monophosphate (cGMP). When this happens, levels of cGMP increase, which causes the smooth muscles in the penis to relax and improve blood flow. This leads to an erection.

It is important to review the patient’s medical history and current medications, as many diseases and medications can cause erectile dysfunction. It is also important to determine whether the symptoms are due to a psychologic cause, as this may affect adherence to medication. Additionally, patients should be screened for any cardiovascular disease and diabetes mellitus, as these are commonly associated with erectile dysfunction.